Villa Migone hosts and has hosted numerous cultural events, book presentations, guided tours and was the set of film productions (Il segreto della Pedona) and music videos (Idea 9 of Gnu Quartet).

On 2 and 3 April 2016 Villa Migone participated in the Rolli Days organized by the Municipality of Genoa, registering over 2400 visitors.

Every April 25, on the occasion of the commemorations of the Liberation, the Villa is open to citizens.